Hydrochloric Acid → HCID 22710671, compound

HRID 352938Notes

Reaction equation

HRID 352938 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([S:13]([N:16]1[CH2:21][CH2:20][N:19]([C:22]([C:24]3[S:32][C:31]4[CH2:30][CH2:29][NH:28][CH2:27][C:26]=4[CH:25]=3)=[O:23])[CH:18]([C:33]([O:35]CC)=[O:34])[CH2:17]1)(=[O:15])=[O:14])[CH:7]=[CH:6]2.C(O)C.[OH-].[Na+].Cl>O1CCCC1>[ClH:2].[C:33]([CH:18]1[CH2:17][N:16]([S:13]([C:8]2[CH:7]=[CH:6][C:5]3[C:10](=[CH:11][CH:12]=[C:3]([Cl:2])[CH:4]=3)[CH:9]=2)(=[O:15])=[O:14])[CH2:21][CH2:20][N:19]1[C:22]([C:24]1[S:32][C:31]2[CH2:30][CH2:29][NH:28][CH2:27][C:26]=2[CH:25]=1)=[O:23])([OH:35])=[O:34]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 22710215HCID 22710215, compound

Product 1

HCID 22710671HCID 22710671, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In tetrahydrofuran (1 ml), 4-[(6-chloronaphthalen-2-yl)sulfonyl]-2-ethoxycarbonyl-1-[(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)carbonyl]piperazine hydrochloride (95 mg) was dissolved, followed by the addition of ethanol (2 ml) and 1N sodium hydroxide (3 ml). The resulting mixture was heated under reflux for 30 minutes. To the reaction mixture, 4N hydrochloric acid (2 ml) was added and the precipitate thus obtained was collected by filtration, whereby the title compound (83 mg, 90%) was obtained as a colorless foam.

Workup

  1. temperatureThe resulting mixture was heated
  2. temperatureunder reflux for 30 minutes
  3. customthe precipitate thus obtained
  4. filtrationwas collected by filtration, whereby the title compound (83 mg, 90%)
  5. customwas obtained as a colorless foam

Sources & evidence

ORD record
ord-d3b240cd87b543cda94dbf49f465ff64
Source dataset
uspto-grants-2004_06
Patent number
US06747023B1

Reaction notes

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