Trifluoroacetic acid → HCID 69881589, compound

HRID 352974Notes

Reaction equation

HRID 352974 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([N:15]1[CH2:20][CH2:19][N:18]([C:21]([C:23]3[S:24][C:25]4[CH2:26][NH:27][CH:28]([CH2:32][C:33]([O:35]C(C)(C)C)=[O:34])[CH2:29][C:30]=4[N:31]=3)=[O:22])[CH2:17][CH2:16]1)(=[O:14])=[O:13])[CH:6]=[CH:5]2.[F:40][C:41]([F:46])([F:45])[C:42]([OH:44])=[O:43]>C(Cl)Cl>[F:40][C:41]([F:46])([F:45])[C:42]([OH:44])=[O:43].[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([N:15]1[CH2:20][CH2:19][N:18]([C:21]([C:23]3[S:24][C:25]4[CH2:26][NH:27][CH:28]([CH2:32][C:33]([OH:35])=[O:34])[CH2:29][C:30]=4[N:31]=3)=[O:22])[CH2:17][CH2:16]1)(=[O:14])=[O:13])[CH:6]=[CH:5]2

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86592091HCID 86592091, compound

Product 1

HCID 69881589HCID 69881589, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In methylene chloride (1 ml) was dissolved tert-butyl [2-[[4-[(6-chloronaphthalen-2-yl)sulfonyl]piperazin-1-yl]carbonyl]-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-6-yl)acetate (200 mg), followed by the addition of trifluoroacetic acid (2 ml). The resulting mixture was stirred at room temperature for 2 hours. After concentration under reduced pressure, diethyl ether was added to the residue. The precipitate so formed was collected by filtration, whereby the title compound (193 mg) was obtained as a colorless foam.

Workup

  1. concentrationAfter concentration under reduced pressure, diethyl ether
  2. additionwas added to the residue
  3. customThe precipitate so formed
  4. filtrationwas collected by filtration, whereby the title compound (193 mg)
  5. customwas obtained as a colorless foam

Sources & evidence

ORD record
ord-54e2a7f17c414988a04fec6518102959
Source dataset
uspto-grants-2004_06
Patent number
US06747023B1

Reaction notes

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