Trifluoroacetic acid → HCID 22710032, compound

HRID 352981Notes

Reaction equation

HRID 352981 reaction equation
C(OC([CH:8]1[NH:13][CH2:12][C:11]2[O:14][C:15]([C:17]([N:19]3[CH2:24][CH2:23][N:22]([S:25]([C:28]4[NH:29][C:30]5[C:35]([CH:36]=4)=[CH:34][C:33]([Cl:37])=[CH:32][CH:31]=5)(=[O:27])=[O:26])[CH2:21][CH:20]3[CH2:38][CH3:39])=[O:18])=[N:16][C:10]=2[CH2:9]1)=O)(C)(C)C.[F:40][C:41]([F:46])([F:45])[C:42]([OH:44])=[O:43]>C(Cl)Cl>[F:40][C:41]([F:46])([F:45])[C:42]([OH:44])=[O:43].[Cl:37][C:33]1[CH:34]=[C:35]2[C:30](=[CH:31][CH:32]=1)[NH:29][C:28]([S:25]([N:22]1[CH2:23][CH2:24][N:19]([C:17]([C:15]3[O:14][C:11]4[CH2:12][NH:13][CH2:8][CH2:9][C:10]=4[N:16]=3)=[O:18])[CH:20]([CH2:38][CH3:39])[CH2:21]1)(=[O:27])=[O:26])=[CH:36]2

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22709927HCID 22709927, compound

Product 1

HCID 22710032HCID 22710032, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 1-[[6-(tert-butoxycarbonyl)-4,5,6,7-tetrahydrooxazolo[5,4-c]pyridin-2-yl]carbonyl]-4-[(5-chloroindol-2-yl)sulfonyl]-2-ethylpiperazine (320 mg) in methylene chloride (5.0 ml) was added trifluoroacetic acid (5.0 ml) at room temperature, followed by stirring for 10 minutes. The reaction mixture was concentrated under reduced pressure, whereby the title compound (423 mg) was obtained as a pale brown solid.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure, whereby the title compound (423 mg)
  2. customwas obtained as a pale brown solid

Sources & evidence

ORD record
ord-ac0b885553ec446cbecf80d013ed9346
Source dataset
uspto-grants-2004_06
Patent number
US06747023B1

Reaction notes

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