反应详情

36.3 g (0.3 mol) of p-aminobenzaldehyde are suspended in 450 ml of isopropanol. A mixture of 59.1 g (0.3 mol) of 2-ethylhexyl cyanoacetate and of catalyst (0.375 ml of diethylamine and 1.125 ml of acetic acid) is introduced therein. The mixture is refluxed for 5 hours. The same amount of catalyst is added again and refluxing is continued for a further 4 hours. The insoluble materials are removed by hot filtration and the mixture is concentrated to a volume of 300 ml and left to crystalize. After filtration and drying, 59.6 g (66% yield) of an orange-coloured powder are obtained, and are used without further purification for the following step.

1. temperatureThe mixture is refluxed for 5 hours
2. additionThe same amount of catalyst is added again
3. temperaturerefluxing
4. customThe insoluble materials are removed by hot filtration
5. concentrationthe mixture is concentrated to a volume of 300 ml
6. waitleft
7. customto crystalize
8. filtrationAfter filtration
9. customdrying