HCID 86587979, compound → HCID 22707298, compound

HRID 353061Notes

Reaction equation

HRID 353061 reaction equation
O1CCCCC1[O:7][NH:8][C:9](=[O:31])[C:10]1[CH:15]=[CH:14][C:13]([S:16](=[O:21])(=[O:20])[N:17]([CH3:19])[CH3:18])=[CH:12][C:11]=1[NH:22][C:23]1[CH:28]=[CH:27][C:26]([I:29])=[CH:25][C:24]=1[Cl:30]>Cl.CO.C(O)C>[Cl:30][C:24]1[CH:25]=[C:26]([I:29])[CH:27]=[CH:28][C:23]=1[NH:22][C:11]1[CH:12]=[C:13]([S:16](=[O:21])(=[O:20])[N:17]([CH3:19])[CH3:18])[CH:14]=[CH:15][C:10]=1[C:9]([NH:8][OH:7])=[O:31]

Participants

5

Reactant 1

HCID 86587979HCID 86587979, compound

Product 1

HCID 22707298HCID 22707298, compound

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolventHCID 887MethanolSolvent

Procedure

The compound 2-(2-chloro-4-iodo-phenylamino)-4-dimethylsulfamoyl-benzoic acid O-(tetrahydro-2H-pyran-2-yl)-oxyamide is dissolved in an appropriate hydrogen chloride-saturated solvent like methanol or ethanol. Once homogeneous, the solution is concentrated in vacuo to give the desired product. The product may be triturated with an appropriate solvent like chloroform or dichloromethane if further purification is necessary.

Workup

  1. concentrationOnce homogeneous, the solution is concentrated in vacuo

Sources & evidence

ORD record
ord-cb0830ebcaa84aad91c48e3968a060eb
Source dataset
uspto-grants-2004_06
Patent number
US06750217B2

Reaction notes

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