Sodium Iodide → HCID 21877082, compound

3-Chloro-2,4-pentanedione (723 μL, 6.07 mmol) and then sodium iodide (910 mg, 6.07 mmol) were added to a stirred suspension of 3,5-dichlorothiophenol (1.09 g, 6.07 mmol) and potassium carbonate (923 mg, 6.68 mmol) in acetone (30 ml), at room temperature, in a flask equipped with a calcium chloride drying tube. The mixture became yellow, then orange and finally red accompanied by a slight exotherm and was stirred for 23 hours at room temperature. The mixture was diluted with water (20 ml) and concentrated under reduced pressure in a fumehood (Caution: possible residual lachrymator) to remove acetone. The residue was diluted with 2M hydrochloric acid (20 ml) and extracted with dichloromethane (1×40 ml, 2×20 ml). The combined organic phases were washed with brine (20 ml), dried over anhydrous magnesium sulphate, filtered and evaporated under reduced pressure to leave an orange solid (1.66 g). The crude product was purified by flash chromatography on silica gel eluting with pentane:diethyl ether (99:1, by volume) to give the title compound (807 mg) as a yellow solid m.p. 79-81° C.

1. customequipped with a calcium chloride drying tube
2. concentrationconcentrated under reduced pressure in a fumehood (Caution: possible residual lachrymator)
3. customto remove acetone
4. additionThe residue was diluted with 2M hydrochloric acid (20 ml)
5. extractionextracted with dichloromethane (1×40 ml, 2×20 ml)
6. washThe combined organic phases were washed with brine (20 ml)
7. dry with materialdried over anhydrous magnesium sulphate
8. filtrationfiltered
9. customevaporated under reduced pressure

ORD record

ord-4ed9ce992d174616bf53a3e53f9868fa

Source dataset

uspto-grants-2004_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06750230B2