Trifluoroacetic acid → HCID 22708225, compound

HRID 353173Notes

Reaction equation

HRID 353173 reaction equation
[CH3:1][O:2][C:3]1[C:8]([CH3:9])=[CH:7][C:6]([NH:10][C:11](=[O:38])[CH2:12][N:13]([CH2:20][C:21]2[CH:26]=[CH:25][C:24]([CH2:27][C:28]([CH3:37])([CH3:36])[C:29]([O:31]C(C)(C)C)=[O:30])=[CH:23][CH:22]=2)[CH2:14][C:15]2[O:16][CH:17]=[CH:18][CH:19]=2)=[C:5]([CH3:39])[CH:4]=1.FC(F)(F)C(O)=O>ClCCl>[CH3:1][O:2][C:3]1[C:8]([CH3:9])=[CH:7][C:6]([NH:10][C:11](=[O:38])[CH2:12][N:13]([CH2:20][C:21]2[CH:22]=[CH:23][C:24]([CH2:27][C:28]([CH3:36])([CH3:37])[C:29]([OH:31])=[O:30])=[CH:25][CH:26]=2)[CH2:14][C:15]2[O:16][CH:17]=[CH:18][CH:19]=2)=[C:5]([CH3:39])[CH:4]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22708239HCID 22708239, compound

Product 1

HCID 22708225HCID 22708225, compoundYield 87.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Similarly to the procedure of Example 1-9, 170 mg (0.318 mmol) of tert-butyl 3-(4-{[(2-(4-methoxy-2,5-dimethylphenyl)amino-2-oxoethyl)(2-furylmethyl)amino]methyl}phenyl)-2,2-dimethylpropionate (Example 1-2) are reacted with 1 ml of trifluoroacetic acid in 1 ml of dichloromethane to give 133 mg (87%) of 3-(4-{[(2-(4-methoxy-2,5-dimethylphenyl)amino-2-oxoethyl)(2-furylmethyl)amino]methyl}phenyl)-2,2-dimethylpropionic acid.

Sources & evidence

ORD record
ord-55bfa56bf2164a5eb8f67200f45e7a64
Source dataset
uspto-grants-2004_06
Patent number
US06750236B2

Reaction notes

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