Trifluoroacetic acid → HCID 22708164, compound

HRID 353175Notes

Reaction equation

HRID 353175 reaction equation
[CH3:1][O:2][C:3]1[C:8]([CH3:9])=[CH:7][C:6]([NH:10][C:11]([CH:13]([NH:16][CH2:17][C:18]2[CH:34]=[CH:33][C:21]([O:22][C:23]([CH3:32])([CH3:31])[C:24]([O:26]C(C)(C)C)=[O:25])=[CH:20][CH:19]=2)[CH2:14][CH3:15])=[O:12])=[C:5]([CH3:35])[CH:4]=1.FC(F)(F)C(O)=O>ClCCl>[CH3:1][O:2][C:3]1[C:8]([CH3:9])=[CH:7][C:6]([NH:10][C:11]([CH:13]([NH:16][CH2:17][C:18]2[CH:19]=[CH:20][C:21]([O:22][C:23]([CH3:32])([CH3:31])[C:24]([OH:26])=[O:25])=[CH:33][CH:34]=2)[CH2:14][CH3:15])=[O:12])=[C:5]([CH3:35])[CH:4]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22708170HCID 22708170, compound

Product 1

HCID 22708164HCID 22708164, compoundYield 98.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Similarly to the procedure of Example 1-9, 115 mg (0.237 mmol) of tert-butyl 2-(4-{[(1-{[(4-methoxy-2,5-dimethylphenyl)amino]carbonyl}propyl)amino]methyl}phenoxy)-2-methylpropionate (Example 1-8) are reacted with 0.46 ml (5.93 mmol) of trifluoroacetic acid in 3 ml of dichloromethane to give 100 mg (93%) of 2-(4-{[(1-{[(4-methoxy-2,5-dimethylphenyl)amino]carbonyl}propyl)amino]methyl}phenoxy)-2-methylpropionic acid.

Sources & evidence

ORD record
ord-17c8ffaa05fc47be8b276de95de322ea
Source dataset
uspto-grants-2004_06
Patent number
US06750236B2

Reaction notes

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