反应详情

117 g of triethylamine and 140 g of 2,4-dimethylaniline are dissolved in 2 l of methylene chloride, and a solution of 233 g of alpha-bromoacetyl bromide in 400 ml of methylene chloride is added with ice-cooling, at at most 15° C., within 30 min. After a reaction time of 30 min, the precipitate is filtered off with suction, the residue is dissolved in 3 l of methylene chloride and combined with the filtrate and washed twice with 2 l of water and 2 l of sat. sodium chloride solution. The mixture is dried over sodium sulphate, filtered off with suction and concentrated, and the residue is recrystallized from ethanol. This gives 193 g of the title compound.

1. temperaturecooling, at at most 15° C., within 30 min
2. filtrationAfter a reaction time of 30 min, the precipitate is filtered off with suction
3. dissolutionthe residue is dissolved in 3 l of methylene chloride
4. washwashed twice with 2 l of water and 2 l of sat. sodium chloride solution
5. dry with materialThe mixture is dried over sodium sulphate
6. filtrationfiltered off with suction
7. concentrationconcentrated
8. customthe residue is recrystallized from ethanol