反应详情

(E)-1,3-Di(3-fluorophenyl)-2-propen-1-one (16.4 g, 67.2 mmol), 2-cyanoacetamide (6.21 g, 73.9 mmol), and a solution of potassium t-butoxide (30.2 g, 269 mmol) in dimethyl sulfoxide (131 mL) were stirred overnight at room temperature in an oxygen atmosphere. Water (300 mL) and 6 N hydrochloric acid (390 mL) were added to the reaction solution. The solid was collected by filtration and washed with water, to give the title compound (17.4 g, 84%).

1. filtrationThe solid was collected by filtration
2. washwashed with water