Lithium Hydroxide → HCID 9848765, compound

HRID 353295Notes

Reaction equation

HRID 353295 reaction equation
[CH2:1]([C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH:15]([O:21][CH2:22][CH3:23])[C:16]([O:18]CC)=[O:17])=[CH:10][C:9]=1[O:24][CH2:25][CH2:26][C:27]1[CH:32]=[CH:31][C:30]([O:33][S:34]([CH3:37])(=[O:36])=[O:35])=[CH:29][CH:28]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Li+].[OH-].C1COCC1.S([O-])(O)(=O)=O.[K+]>O.C(O)C>[CH2:1]([C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH:15]([O:21][CH2:22][CH3:23])[C:16]([OH:18])=[O:17])=[CH:10][C:9]=1[O:24][CH2:25][CH2:26][C:27]1[CH:32]=[CH:31][C:30]([O:33][S:34]([CH3:37])(=[O:35])=[O:36])=[CH:29][CH:28]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

7

Reactant 4

HCID 3939Lithium HydroxideHCID 8028TetrahydrofuranHCID 516920Potassium bisulfateHCID 10208512HCID 10208512, compound

Product 1

HCID 9848765HCID 9848765, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

Ethyl 3-[4-benzyl-3-({4-[(methylsulfonyl)oxy]phenethyl}oxy)phenyl]-2-ethoxypropanoate (0.48 g), LiOH (0.024 g), THF (10 ml), ethanol (2 ml) and water (2 ml) were added to a reaction flask. The solution was stirred 4 h at room temperature. Aqueous solution, 1 M, of potassium hydrogen sulfate (2 ml) was added to the reaction flask. The solvent was evaporated. The residue was extracted twice by ethyl acetate. The organic phase was dried by magnesium sulfate and filtered. The solvent was evaporated and the product isolated (0.4 g).

Workup

  1. customThe solvent was evaporated
  2. extractionThe residue was extracted twice by ethyl acetate
  3. dry with materialThe organic phase was dried by magnesium sulfate
  4. filtrationfiltered
  5. customThe solvent was evaporated
  6. customthe product isolated (0.4 g)

Sources & evidence

ORD record
ord-467419782533411387e00c61394f6e58
Source dataset
uspto-grants-2004_06
Patent number
US06750252B2

Reaction notes

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