Allyl bromide → HCID 23514064, compound

HRID 353472Notes

Reaction equation

HRID 353472 reaction equation
C(OC[C:6]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:7]=1[CH:8]=[CH:9][N:10]2[CH2:15][C:16]1[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=1)C=C.ClC1C=CC(CN2C3C(=[C:33]([CH2:38][OH:39])C=CC=3)C=C2)=CC=1.C(Br)C=C.[H-].[Na+]>CN(C=O)C>[Cl:22][C:19]1[CH:18]=[CH:17][C:16]([CH2:15][N:10]2[C:11]3[C:7](=[C:6]([CH:38]([OH:39])[CH3:33])[CH:14]=[CH:13][CH:12]=3)[CH:8]=[CH:9]2)=[CH:21][CH:20]=1

Participants

6

Reactant 4

HCID 7841Allyl bromideHCID 24758Sodium hydrideHCID 23514081HCID 23514081, compoundHCID 86589021HCID 86589021, compound

Product 1

HCID 23514064HCID 23514064, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2-[4-[(allyloxy)methyl]-1-(4-chlorobenzyl)-1H-indole, oil (prepared by alkylation of [1-(4-chlorobenzyl)-1H-indol-4-yl]methanol with allyl bromide in DMF in the presence of NaH, at room temperature for 3 h).

Sources & evidence

ORD record
ord-29b3c7d45e7045e98f47dc46b77f67e2
Source dataset
uspto-grants-2004_06
Patent number
US06753342B2

Reaction notes

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