反应详情

5-Amino-1-methyl-1H-pyrazole-4-carbonitrile (1.0 eq) and ethyl 1H-benzimidazol-2-ylacetate (1.0 eq) were dissolved in THF and dried over sieves. LiHMDS (3 eq) was added dropwise and the mixture stirred for 18 hours. The mixture was filtered and diluted with EtOAc, then washed with an aqueous saturated NH4Cl solution. The aqueous layer was washed with EtOAc (3×), and the organic layers combined, dried over MgSO4, and concentrated yielding pure product. LC/MS m/z 281.0 (MH+), Rt 1.41 minutes.

1. customdried over sieves
2. filtrationThe mixture was filtered
3. additiondiluted with EtOAc
4. washwashed with an aqueous saturated NH4Cl solution
5. washThe aqueous layer was washed with EtOAc (3×)
6. dry with materialdried over MgSO4
7. concentrationconcentrated
8. customyielding pure product