Hydrochloric Acid → 2-Aminomethyl-4-(1,1-dimethylethyl)-6-methylsulfamoylphenol hydrochloride

HRID 35403Notes

Reaction equation

HRID 35403 reaction equation
C([NH:4][CH2:5][C:6]1[C:11]([OH:12])=[C:10]([S:13](=[O:17])(=[O:16])[NH:14][CH3:15])[CH:9]=[C:8]([C:18]([CH3:21])([CH3:20])[CH3:19])[CH:7]=1)(=O)C.[ClH:22]>C(O)C>[ClH:22].[NH2:4][CH2:5][C:6]1[CH:7]=[C:8]([C:18]([CH3:20])([CH3:21])[CH3:19])[CH:9]=[C:10]([S:13](=[O:17])(=[O:16])[NH:14][CH3:15])[C:11]=1[OH:12]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 132103502-Acetamidomethyl-4-(1,1-dimethylethyl)-6-methylsulfamoylphenol

Product 1

HCID 212969082-Aminomethyl-4-(1,1-dimethylethyl)-6-methylsulfamoylphenol hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4.9 g (0.016 mole) of 6-acetamidomethyl-4-(1,1-dimethylethyl)-2-methylsulfamoylphenol in a mixture of 30 ml of ethanol and 10 ml of concentrated hydrochloric acid are heated under reflux for 8 hours. Evaporation and recrystallization from methanol/ether gives white crystals of melting point 238°-240° C.

Workup

  1. temperatureare heated
  2. temperatureunder reflux for 8 hours
  3. customEvaporation and recrystallization from methanol/ether
  4. customgives white crystals of melting point 238°-240° C.

Sources & evidence

ORD record
ord-da580e455ab5437193e566ed18538d68
Source dataset
uspto-grants-1988_08
Patent number
US04766241

Reaction notes

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