反应详情

To a solution of 3-methoxybenzenethiol (15.0 mL, 120 mmol) and potassium carbonate (16.6 gm, 120 mmol) in 150 mL of acetone at room temperature was added dropwise 2-bromo-1,1-diethoxy-ethane (16.5 mL, 110 mmol). The reaction mixture was stirred at room temperature for 16 hours. The solids in the reaction mixture were removed by filtration and were washed well with acetone. The filtrate was concentrated. The residue was diluted with water and extracted several times with ether. The ether layers were combined and washed with 0.5 M KOH, water, brine, and were then dried over anhydrous sodium sulfate, filtered, and concentrated to yield 28.2 gm of the title compound.

1. customThe solids in the reaction mixture were removed by filtration
2. washwere washed well with acetone
3. concentrationThe filtrate was concentrated
4. additionThe residue was diluted with water
5. extractionextracted several times with ether
6. washwashed with 0.5 M KOH, water, brine
7. dry with materialwere then dried over anhydrous sodium sulfate
8. filtrationfiltered
9. concentrationconcentrated