Methanethiol → HCID 22628432, compound

HRID 354232Notes

Reaction equation

HRID 354232 reaction equation
Cl[C:2]1[C:3]([CH3:20])=[C:4]([C:14]2[O:18][N:17]=[C:16]([CH3:19])[CH:15]=2)[C:5]([CH3:13])=[C:6]([CH:12]=1)[C:7]([O:9][CH2:10][CH3:11])=[S:8].C(=O)([O-])[O-].[K+].[K+].CS>CN(C=O)C>[CH3:13][C:5]1[C:4]([C:14]2[O:18][N:17]=[C:16]([CH3:19])[CH:15]=2)=[C:3]([CH3:20])[CH:2]=[CH:12][C:6]=1[C:7]([O:9][CH2:10][CH3:11])=[S:8]

Participants

5

Reactant 3

HCID 878MethanethiolHCID 11430Potassium CarbonateHCID 86759467HCID 86759467, compound

Product 1

HCID 22628432HCID 22628432, compoundYield 65.3%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

0.50 g of the obtained ethyl 5-chloro-2-methyl-3-(3-methylisoxazol-5-yl)-4-methylthiobenzoate and 1.06 g of potassium carbonate were added to 15 ml of DMF, and further a solution of 0.36 g of methyl mercaptan dissolved in 5 ml of DMF was dropped at room temperature. The resulting solution was stirred at room temperature for 23 hours. The same procedure as that in Example 1 was repeated to give 0.29 g of the title compound as white crystals. 0.08 g of ethyl 5-chloro-2-methyl-3-(3-methylisoxazol-5-yl)-4-methylthiobenzoate was recovered.

Workup

  1. additionwas dropped at room temperature

Sources & evidence

ORD record
ord-0e68c949da054f5b9b9a37df065f17fc
Source dataset
uspto-grants-2004_06
Patent number
US06756497B1

Reaction notes

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