反应详情

25 g of 2,3-dimethyl-4-nitropyridine 1-oxide are dissolved in 1250 ml of n-propanol and the solution is stirred at 120° under argon for 16 days. The reaction mixture is concentrated, whereupon the residue is treated with methylene chloride-water and extracted. The organic phases are dried and concentrated. The residue is chromatographed on silica gel and purified with methylene chloride-methanol (20:1, 10:1), the medium pressure flash chromatography method being used and the pressure being produced with nitrogen gas. The 2,3-dimethyl-4-propoxypyridine 1-oxide obtained is processed directly.

1. concentrationThe reaction mixture is concentrated, whereupon the residue
2. additionis treated with methylene chloride-water
3. extractionextracted
4. customThe organic phases are dried
5. concentrationconcentrated
6. customThe residue is chromatographed on silica gel
7. custompurified with methylene chloride-methanol (20:1, 10:1)
8. customthe pressure being produced with nitrogen gas