Pyrrolidine → HCID 12834686, compound

HRID 354777Notes

Reaction equation

HRID 354777 reaction equation
[Cl:1][CH2:2][CH2:3][C:4]([N:6]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[C:10](=[O:17])[N:9]([CH3:18])[C:8]2[CH:19]=[CH:20][CH:21]=[CH:22][C:7]1=2)=[O:5].[NH:23]1[CH2:27][CH2:26][CH2:25][CH2:24]1>C(O)(C)C>[ClH:1].[CH3:18][N:9]1[C:10](=[O:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[N:6]([C:4](=[O:5])[CH2:3][CH2:2][N:23]2[CH2:27][CH2:26][CH2:25][CH2:24]2)[C:7]2[CH:22]=[CH:21][CH:20]=[CH:19][C:8]1=2

Participants

4

Reactant 2

HCID 31268PyrrolidineHCID 13646314HCID 13646314, compound

Product 1

HCID 12834686HCID 12834686, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

4.5 gm (0.015 mol) of 5-(3-chloro-propionyl)-5,10-dihydro-10-methyl-11H-dibenzo[b,e][1,4]diazepin-11-one and 2.6 gm (0.0375 mol) of pyrrolidine were refluxed for 2 hours in 45 ml of isopropanol. The reaction mixture was worked up as described in Example 1.

Sources & evidence

ORD record
ord-6a188074199746449759e302eb909b66
Source dataset
uspto-grants-1983_03
Patent number
US04377576

Reaction notes

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