Piperidine → 5,10-Dihydro-5-[3-(piperidino)-propionyl]-11H-dibenzo[b,e][1,4]diazepin-11-one hydrochloride

HRID 354779Notes

Reaction equation

HRID 354779 reaction equation
[Cl:1][CH2:2][CH2:3][C:4]([N:6]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[C:10](=[O:17])[NH:9][C:8]2[CH:18]=[CH:19][CH:20]=[CH:21][C:7]1=2)=[O:5].[NH:22]1[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1>C(O)(C)C>[ClH:1].[N:22]1([CH2:2][CH2:3][C:4]([N:6]2[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[C:10](=[O:17])[NH:9][C:8]3[CH:18]=[CH:19][CH:20]=[CH:21][C:7]2=3)=[O:5])[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 128346825-(3-chloro-propionyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one

Product 1

HCID 128346905,10-Dihydro-5-[3-(piperidino)-propionyl]-11H-dibenzo[b,e][1,4]diazepin-11-one hydrochlorideYield 69%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

60.0 gm (0.2 mol) of 5-(3-chloro-propionyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one and 42.5 gm (0.5 mol) of piperidine were refluxed in 600 ml of isopropanol and worked up as described in Example 1. 53 gm of the hydrochloride (recrystallized from n-propanol), m.p. 250°-252° C., were obtained

Sources & evidence

ORD record
ord-8fd89280d06d453996f879c389197645
Source dataset
uspto-grants-1983_03
Patent number
US04377576

Reaction notes

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