反应详情

A mixture containing 6 g (0.025 mole) of 2-phenyl-4-chloroquinazoline, 3.53 g (0.035 mole) of 4-hydroxypiperidine and 100 ml of 95% ethyl alcohol was refluxed for 3 hrs. One gram of sodium hydroxide (in one ml of water) was added and the mixture was refluxed for an additional 2 hr period. The mixture was filtered and the filtrate was added to 300 ml of water. The white crystalline precipitate was separated and recrystallized with methanol and water to give 3.2 g of the title compound, m.p. 165°-167° C.

1. temperaturewas refluxed for 3 hrs
2. temperaturethe mixture was refluxed for an additional 2 hr period
3. filtrationThe mixture was filtered
4. additionthe filtrate was added to 300 ml of water
5. customThe white crystalline precipitate was separated
6. customrecrystallized with methanol and water