反应详情

温度

155 °C

A mixture of 4-amino-6-methanesulfonamidoquinazoline (6.89 g), diethyl ethoxymethylenepropanediate (15.5 g) and N,N-dimethylformamide (55 ml) was stirred at 155° C. for 2.5 hours. The reaction mixture was cooled to ambient temperature. To the mixture was added water to give precipitates, which were separated by filtration and washed with water. To the crystals was added a mixture of methanol and chloroform (1:4) (400 ml). After stirring under heating, insoluble materials (6.95 g) were filtered off and recrystallized from N,N-dimethylformamide to give crystalline ethyl 4-oxo-10-methanesulfonamido-4H-pyrimido [1,2-c]quinazoline-3-carboxylate (5.76 g).

1. temperatureThe reaction mixture was cooled to ambient temperature
2. customto give
3. customprecipitates
4. customwhich were separated by filtration
5. washwashed with water
6. additionTo the crystals was added
7. additiona mixture of methanol and chloroform (1:4) (400 ml)
8. stirringAfter stirring
9. temperatureunder heating
10. filtrationinsoluble materials (6.95 g) were filtered off
11. customrecrystallized from N,N-dimethylformamide