反应详情

To 30 ml of dihydropyran containing 450 mg of p-toluenesulfonyl chloride is added 6.0 g of the product of Step B and the solution is stirred at room temperature for 1 hour. The solution is the diluted with ethyl ether and washed with a 20% pyridine water mixture twice, and then water, then brine, and dried and evaporated to yield a pale yellow oil which crystallizes (8.5 g), and has a m.p. of 92°-96° C.

1. washwashed with a 20% pyridine water mixture twice
2. dry with materialwater, then brine, and dried
3. customevaporated
4. customto yield a pale yellow oil which
5. customcrystallizes (8.5 g)