反应详情

2,4-Dimethyl-5-(trifluoromethanesulfonamido)benzenesulfonyl chloride (1.5 g) was added to tetrahydrofuran (20 ml) containing propargylamine (0.5 g), and the resultant mixture was allowed to stand overnight at room temperature. Upon completion of the reaction, the mixture was concentrated. A 5% aqueous solution of hydrochloric acid was added to the residue, whereby an oily substance was deposited. The oily substance was extracted with chloroform and washed with a 5% aqueous solution of hydrochloric acid and water in order. The extract was concentrated and recrystallized from toluene to give 1.05 g of N-propargyl-2,4-dimethyl-5-(trifluoromethanesulfonamido)benzenesulfonamide (Compound No. 35). M.P., 130.5°-132° C.

1. customUpon completion of the reaction
2. concentrationthe mixture was concentrated
3. additionA 5% aqueous solution of hydrochloric acid was added to the residue, whereby an oily substance
4. extractionThe oily substance was extracted with chloroform
5. washwashed with a 5% aqueous solution of hydrochloric acid and water in order
6. concentrationThe extract was concentrated
7. customrecrystallized from toluene