反应详情

To a solution of N-methyl-2,4-dimethyl-5-(trifluoromethanesulfonamido)benzenesulfonamide (2 g) and triethylamine (0.7 g) in tetrahydrofuran (20 ml), propionyl chloride (0.45 g) was added, and the resultant mixture was allowed to stand at room temperature overnight. The reaction mixture was concentrated, admixed with 5% hydrochloric acid and extracted with chloroform. The extract was concentrated to give an oily substance, which was purified by silica gel chromatography. Recrystallization from a mixture of toluene and hexane gave 1.17 g of N-methyl-2,4-dimethyl-5-(N-propionyl-N-trifluoromethanesulfonylamino)benzenesulfonamide (Compound No. 81). M.P., 101°-103° C.

1. concentrationThe reaction mixture was concentrated
2. extractionextracted with chloroform
3. concentrationThe extract was concentrated
4. customto give an oily substance, which
5. customwas purified by silica gel chromatography
6. customRecrystallization
7. additionfrom a mixture of toluene and hexane