1-Chloro-4-(chloromethyl)benzene → HCID 12961174, compound

HRID 355046Notes

Reaction equation

HRID 355046 reaction equation
[H-].[Na+].[CH3:3][O:4][C:5](=[O:23])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[NH:15][C:14]1=[O:22].[Cl:24][C:25]1[CH:32]=[CH:31][C:28]([CH2:29]Cl)=[CH:27][CH:26]=1>CN(C=O)C>[CH3:3][O:4][C:5](=[O:23])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[N:15]([CH2:29][C:28]2[CH:31]=[CH:32][C:25]([Cl:24])=[CH:26][CH:27]=2)[C:14]1=[O:22]

Participants

5

Reactant 3

HCID 77231-Chloro-4-(chloromethyl)benzeneHCID 24758Sodium hydrideHCID 129611718-(2-Oxobenzimidazolin-1-yl)-caprylic acid methyl ester

Product 1

HCID 12961174HCID 12961174, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The product is produced as described in example 1 from 0.72 g. of NaH (80% suspension in mineral oil), 7 g. of 8-(2-oxo-benzimidazolin-1-yl)-caprylic acid methyl ester, 100 cc. of DMF, 3.9 g. of 4-chlorobenzylchloride and 0.72 g. of NaJ Eluant in chromatographic purification: hexane/ethylacetate.

Workup

  1. customThe product is produced
  2. customof NaJ Eluant in chromatographic purification

Sources & evidence

ORD record
ord-4926135b1b0b48538f6c3555a43f3a05
Source dataset
uspto-grants-1983_03
Patent number
US04377695

Reaction notes

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