Sodium hydride → HCID 53945765, compound

HRID 355050Notes

Reaction equation

HRID 355050 reaction equation
[H-].[Na+].[CH3:3][O:4][C:5](=[O:23])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[NH:15][C:14]1=[O:22].[CH3:24][O:25][C:26]1[CH:33]=[CH:32][C:29](CCl)=[CH:28][CH:27]=1>CN(C=O)C>[CH3:3][O:4][C:5](=[O:23])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[N:15]([C:29]2[CH:32]=[CH:33][C:26]([O:25][CH3:24])=[CH:27][CH:28]=2)[C:14]1=[O:22]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 699934-Methyloxybenzyl chlorideHCID 129611718-(2-Oxobenzimidazolin-1-yl)-caprylic acid methyl ester

Product 1

HCID 53945765HCID 53945765, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The product is produced as described in example 1 from 0.72 g. of NaH (80% suspension in mineral oil), 7 g. of 8-(2-oxo-benzimidazolin-1-yl)-caprylic acid methyl ester, 100 cc. of DMF, 3.8 g. of 4-methoxybenzylchloride and 0.72 g. of NaJ. Eluant for chromatographic purification: hexane/ethylacetate.

Workup

  1. customThe product is produced
  2. customEluant for chromatographic purification

Sources & evidence

ORD record
ord-fff027ce25d8475589acac74defa949d
Source dataset
uspto-grants-1983_03
Patent number
US04377695

Reaction notes

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