反应详情

10 g (0.0616 mole) of 2-amino-5-trifluoromethylpyridine and 17.5 g (0.0616 mole) of 1-bromo-2-(4-methylphenyl)-2-ethanone are mixed in 200 ml of n-propanol and the solution is heated to reflux. At the end of the reaction, the reaction mixture is concentrated under reduced pressure and the evaporation residue taken up with water and treated with an excess of ammonia solution until the pH is basic. The imidazopyridine is extracted with dichloromethane and purified by chromatography. 11.95 g (56%) of white solid are obtained. M.p. 187°-188° C.

1. temperaturethe solution is heated to reflux
2. customAt the end of the reaction
3. concentrationthe reaction mixture is concentrated under reduced pressure
4. additiontreated with an excess of ammonia solution until the pH
5. extractionThe imidazopyridine is extracted with dichloromethane
6. custompurified by chromatography