反应详情

67 g (0.62 mole) of 2-amino-5-methylpyridine, 86 g (1.02 mole) of sodium bicarbonate and 143 g (0.527 mole) of ethyl 4-(2-bromoacetyl)benzoate are introduced into 1 l of ethanol. The mixture is brought to reflux for 3 hours and left standing for 19 hours, and the solid formed is recovered by filtration, washed copiously with water and dried. It is recrystallized in a dichloromethane/methanol mixture. M.p. 228°-230° C.

1. temperatureto reflux for 3 hours
2. waitleft
3. customthe solid formed
4. filtrationis recovered by filtration
5. washwashed copiously with water
6. customdried
7. customIt is recrystallized in a dichloromethane/methanol mixture