反应详情

59.5 g (0.2 mole) of 1-bromo-2-(4-nitrophenyl)-2-ethanone, 21.6 g (0.2 mole) of 2-amino-5-methylpyridine and 34 g of sodium bicarbonate are reacted in 200 ml of 95% strength ethanol. Stirring and refluxing are maintained for 3 hours, and the reaction mixture is then cooled and the ethanol evaporated off under reduced pressure. The evaporation residue is stirred in 700 ml of water at 70° C. for 3 hours, and the insoluble material is then filtered off, washed with 50 ml of ethanol and then ether and dried. M.p. 237°-239° C.

1. temperaturerefluxing
2. temperatureare maintained for 3 hours
3. temperaturethe reaction mixture is then cooled
4. customthe ethanol evaporated off under reduced pressure
5. stirringThe evaporation residue is stirred in 700 ml of water at 70° C. for 3 hours
6. filtrationthe insoluble material is then filtered off
7. washwashed with 50 ml of ethanol
8. dry with materialether and dried