Hydrochloric Acid → HCID 54071267, compound
Reaction equation
[F:1][C@@H:2]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])[CH2:3][C:4]([O:6]C)=[O:5].Cl>C(O)(=O)C>[F:1][C@@H:2]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])[CH2:3][C:4]([OH:6])=[O:5]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 90 °C
Procedure
In a two-necked round-bottomed flask, 98 mg (0.52 mM) of methyl (S)-3-fluorononanoate and 1 ml of acetic acid were placed. To the mixture, 1 ml of concentrated hydrochloric acid was added, followed by stirring for 4 hours at 90° C. After the reaction, ice water was added to the reaction mixture, followed by extraction with Et2O. The organic layer was sufficiently washed with distilled water and dried with anhydrous magnesium sulfate, followed by distilling-off of the solvent under reduced pressure to obtain 78 mg (0.44 mM) of (S)-3-fluorononanoic acid.
Workup
- additionwas added to the reaction mixture
- extractionfollowed by extraction with Et2O
- washThe organic layer was sufficiently washed with distilled water
- dry with materialdried with anhydrous magnesium sulfate
Sources & evidence
- ORD record
- ord-1bcbed4aa024460aa27b0a77022ad974
- Source dataset
- uspto-grants-1998_11
- Patent number
- US05830386
Reaction notes
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