反应详情

One hundred and seventy-six (176) grams of ethyl cinnamate, 108 g of phenylhydrazine, 200 ml of a 28% methanol solution containing sodium methoxide, and 400 ml of acetonitrile were mixed and refluxed with heating in the nitrogen atmosphere for 1 hour. The reaction solution was poured into 2 liters of water and 100 ml of concentrated hydrochloric acid was added, thereby precipitation was formed. This was filtered off and recrystallized with acetonitrile to obtain 180 g of 1-phenyl-5-phenylpyrazolidin-3-one (A) as white crystals. ##STR10## Synthesis of Compound (B)

1. additionwere mixed
2. temperaturerefluxed
3. temperaturewith heating in the nitrogen atmosphere for 1 hour
4. additionwas added
5. customprecipitation
6. customwas formed
7. filtrationThis was filtered off
8. customrecrystallized with acetonitrile