Diethyl Ether → HCID 131720912, compound

To a solution of 2-methyl-2-hydroxy-3-butyne (1.68 mL, 20 mmol), and 2,6-lutidine (11 mL, 5 eq) in 15 mL of, was added TBDMSOTf (5 mL, 1.1 eq) dropwise at 0° C. After being stirred for 10 min, the reaction mixture was diluted with ether (100 mL) and then quenched with water. The solution was washed with 5%-HCl solution (×2) and the aqueous layer was extracted with ether (100 mL). The combined solution was washed with saturated aqueous NaHCO3, brine, dried over NaSO4, concentrated in vacuo and then purified by chromatography (2% ether/hexane) to give 2.02 g (50%) of (1,1 dimethyl) [(1,1-dimethyl-2-propoxy)oxy]dimethylsilane as a colorless oil. To a solution of (1,1-dimethyl) [(1,1-dimethyl-2-propoxy)oxy]dimethylsilane (1.87 g, 9.5 mmol) in 10 mL of THF, was added 6.1 mL (10.4 mmol, 1.1 eq) of 1.6M n-BuLi solution in hexane dropwise at -78° C. for 10 min. After being stirred for 10 min, 2 mL (26 mmol) of anhydrous DMF was added to the mixture at -78° C. After 15 min, the reaction was quenched with 1.3 mL (20 mmol) of acetic acid and then allowed to warm to -20° C. The mixture was extracted with hexane (50 mL), and the aqueous layer was extracted with hexane (50 mL). The combined organic extracts were washed with aqueous NH4Cl solution (×2), brine, dried over NaSO4, concentrated in vacuo and then purified by chromatography (10% ether/hexane) to give 1.73 g (81%) of 4-[[(1,1-dimethylethyl)-dimethysilyl]oxy]4-methyl2-pentynal 11 as a colorless oil. (M. Okabe; R. Sun; M. Scalone; C. H. Jibilian; S. D. Hutchings. J. Org. Chem. 1995, 60, 767-771, incorporated herein by reference).

1. customquenched with water
2. washThe solution was washed with 5%-HCl solution (×2)
3. extractionthe aqueous layer was extracted with ether (100 mL)
4. washThe combined solution was washed with saturated aqueous NaHCO3, brine
5. dry with materialdried over NaSO4
6. concentrationconcentrated in vacuo
7. custompurified by chromatography (2% ether/hexane)

ORD record

ord-1982012e211840c7a10c07e7adea6c3c

Source dataset

uspto-grants-1998_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05830885