1H-1,2,4-Triazole → HCID 14837893, compound

HRID 355389Notes

Reaction equation

HRID 355389 reaction equation
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[Na].[NH:13]1[CH:17]=[N:16][CH:15]=[N:14]1>CN(C)C=O>[N:13]1([C:2]2[CH:11]=[CH:10][C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=2)[CH:17]=[N:16][CH:15]=[N:14]1

Participants

5

Reactant 3

HCID 92571H-1,2,4-TriazoleHCID 119282-ChloroquinolineHCID 5360545Sodium

Product 1

HCID 14837893HCID 14837893, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1.64 g of 2-chloro-quinoline and 1.1 g of the sodium salt of 1H-1,2,4-triazole are reacted in 10 ml of dimethyl formamide for 20 hours at 100° C. and worked up as in Example 1 to give 1.43 g of 2-(1H-1,2,4-triazole-1-yl)-quinoline /yield 53%/

Sources & evidence

ORD record
ord-e9ec184903024171ae2582a4dec4ea4c
Source dataset
uspto-grants-1998_11
Patent number
US05830903

Reaction notes

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