Dichloromethane → RU 59063

HRID 355591Notes

Reaction equation

HRID 355591 reaction equation
[CH3:1][C:2]1([CH3:26])[C:6](=N)[N:5]([C:8]2[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[C:10]([C:16]([F:19])([F:18])[F:17])[CH:9]=2)[C:4](=[S:20])[N:3]1[CH2:21][CH2:22][CH2:23][CH2:24][OH:25].C(Cl)Cl.C(OCC)(=[O:32])C>>[CH3:1][C:2]1([CH3:26])[C:6](=[O:32])[N:5]([C:8]2[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[C:10]([C:16]([F:18])([F:19])[F:17])[CH:9]=2)[C:4](=[S:20])[N:3]1[CH2:21][CH2:22][CH2:23][CH2:24][OH:25]

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 8857Ethyl AcetateHCID 22116972HCID 22116972, compound

Product 1

HCID 197655RU 59063

Procedure

Using the procedure of Example 71, 300 mg of the product of Example 76 were reacted to obtain 236 mg of the expected product melting at 78°-79° C. with a Rf=0.31 (eluant: methylene chloride--acetone (75-25)).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-6e101122724b4796b0920631581ec140
Source dataset
uspto-grants-1998_11
Patent number
USRE035956

Reaction notes

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