Methyl vinyl ketone → HCID 21829922, compound

HRID 355649Notes

Reaction equation

HRID 355649 reaction equation
[CH:1]([C:3]([CH3:5])=[O:4])=[CH2:2].[Cl:6][C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][C:8]=1[NH:14][C:15](=[O:20])[C:16]([NH2:19])([CH3:18])[CH3:17]>O1CCCC1>[Cl:6][C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][C:8]=1[NH:14][C:15](=[O:20])[C:16]([NH:19][CH2:2][CH2:1][C:3](=[O:4])[CH3:5])([CH3:17])[CH3:18]

Participants

4

Reactant 2

HCID 6570Methyl vinyl ketoneHCID 21829902HCID 21829902, compound

Product 1

HCID 21829922HCID 21829922, compoundYield 97.4%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Methyl vinyl ketone (1.02 g) was added to a solution of N-(2,5-dichlorophenyl)-2-aminoisobutyramide (2.4 g) in tetrahydrofuran (10 mL) and the mixture was heated at reflux for 30 hours. After distilling off the solvent under reduced pressure, 3 g of N-(2,5-dichlorophenyl)-2-(3-oxobutylamino)isobutyramide was obtained.

Workup

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 30 hours
  3. distillationAfter distilling off the solvent under reduced pressure

Sources & evidence

ORD record
ord-4b09b83902e44bc7aedaeb57c56f6a99
Source dataset
uspto-grants-1998_11
Patent number
US05834401

Reaction notes

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