反应详情

To 2-(5-bromo-2-(phenethyl)phenyl)-4,4-dimethyl-4,5-dihydrooxazole (20 g) in diethyl ether (70 ml) at 0° C. was added DIBAL (168 ml, 1 Mol solution in CH2Cl2). The mixture was stirred at ambient temperature for 18 hours and cooled to 0° C. Aqueous 2N HCl was added to destroy excess DIBAL, the resulting solid was filtered off and suspended in a mixture of water and ethyl acetate. Triethylamine was added until the white solid was dissolved. The organic layer was separated, dried (MgSO4) and evaporated to give 2-(N-(5-bromo-2-(phenethyl)benzyl)amino)-2-methylpropan-1-ol (14.21 g).

1. temperaturecooled to 0° C
2. customto destroy excess DIBAL
3. filtrationthe resulting solid was filtered off
4. additionsuspended in a mixture of water and ethyl acetate
5. additionTriethylamine was added until the white solid
6. dissolutionwas dissolved
7. customThe organic layer was separated
8. dry with materialdried (MgSO4)
9. customevaporated