反应详情

N-Ethyl-N-(2-aminobenzyl)amine (707 mg, 4.7 mmol) in DMF (11 ml) was treated with 6-chloropyridazin-3-amide (4.7 mmol) followed by diisopropylethylamine (15.4 mol) and the reaction stirred at 140° under argon for 24 hours. The reaction was evaporated in vacuo (cold-finger) and the residue partitioned between water and ethyl acetate. The combined organic extracts were dried and evaporated to give a brown gum. The gum was purified by medium pressure chromatography to give 6-(N-ethyl-N-(2-aminobenzyl)amino)-pyridazine-3-carboxamide (500 mg, 30%).

1. customThe reaction was evaporated in vacuo (cold-finger)
2. customthe residue partitioned between water and ethyl acetate
3. customThe combined organic extracts were dried
4. customevaporated
5. customto give a brown gum
6. customThe gum was purified by medium pressure chromatography