4-Phenylpiperidin-4-ol → HCID 18940711, compound

HRID 355821Notes

Reaction equation

HRID 355821 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][N:5]1[C:17]2[CH:16]=[N:15][C:14]([C:18]3[O:22][N:21]=[C:20]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[N:19]=3)=[CH:13][C:12]=2[C:11]2[C:6]1=[CH:7][CH:8]=[CH:9][CH:10]=2.[C:29]1([C:35]2([OH:41])[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]2)[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>CN(C=O)C>[ClH:1].[C:23]1([C:20]2[N:19]=[C:18]([C:14]3[N:15]=[CH:16][C:17]4[N:5]([CH2:4][CH2:3][CH2:2][N:38]5[CH2:37][CH2:36][C:35]([C:29]6[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=6)([OH:41])[CH2:40][CH2:39]5)[C:6]5[C:11]([C:12]=4[CH:13]=3)=[CH:10][CH:9]=[CH:8][CH:7]=5)[O:22][N:21]=2)[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

Participants

4

Reactant 2

HCID 963874-Phenylpiperidin-4-olHCID 18940716HCID 18940716, compound

Product 1

HCID 18940711HCID 18940711, compoundYield 43%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The compound was synthesized by mixing (Compound 9) (0.7 g, 1.8 mmol), 4-phenylpiperidin-4-ol (0.38 g, 2.2 mmol) and TEA (0.55 g, 5.4 mmol) in DMF, in the same manner as illustrated in example 4 to give the title compound (0.47 g, 43%). M.p. 184°-185° C.

Workup

  1. customThe compound was synthesized

Sources & evidence

ORD record
ord-d5dee6dd149d46a6ac22667727482768
Source dataset
uspto-grants-1998_11
Patent number
US05834482

Reaction notes

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