反应详情

A mixture of N-3-hydroxybenzylpiperidine (9.55 g) and anhydrous potassium carbonate (13.8 g) in dimethylformamide (100 ml) was stirred at ambient temperature for 17 hours. 4-Bromobutyronitrile (5 ml) was added and the mixture stirred at ambient temperature for 24 hours. Water (10 volumes) was added and the resulting mixture extracted with ethyl acetate. The extracts were washed with water, dried and the solvent removed to leave an oil which was purified by distillation (190°-200° C./0.1 mm) or by chromatography on a column packed with an activated magnesium silicate (sold under the trade name FLORISIL) to give 4-(3-piperidinomethylphenoxy)butyronitrile as an oil.

1. stirringthe mixture stirred at ambient temperature for 24 hours
2. extractionthe resulting mixture extracted with ethyl acetate
3. washThe extracts were washed with water
4. customdried
5. customthe solvent removed
6. customto leave an oil which
7. distillationwas purified by distillation (190°-200° C./0.1 mm) or by chromatography on a column