Benzyl Bromide → HCID 18940826, compound

HRID 355986Notes

Reaction equation

HRID 355986 reaction equation
[CH2:1]([Br:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:9][O:10][C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[NH:16][CH:15]=[C:14]2[CH2:20][C:21]1[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=1>C(C(C)=O)C>[Br-:8].[CH3:9][O:10][C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[NH:16][CH:15]=[C:14]2[CH2:20][C:21]1[CH:22]=[N+:23]([CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH:24]=[CH:25][CH:26]=1

Participants

4

Reactant 2

HCID 7498Benzyl BromideHCID 18940845HCID 18940845, compound

Product 1

HCID 18940826HCID 18940826, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

Benzyl bromide (8.7 ml; 0.073 mol) was added to a stirring mixture of compound of Description 1 [5-methoxy-3-(pyridin-3-ylmethyl)-1H-indole] (3.5 g; 0.0146 mol) in methyl ethyl ketone (70 ml). The reaction mixture was refluxed for 3 hours. The product precipitated as a yellow solid was filtered and washed with diethyl ether and dried under vacuum. The compound was used as such without further purification.

Workup

  1. temperatureThe reaction mixture was refluxed for 3 hours
  2. customThe product precipitated as a yellow solid
  3. filtrationwas filtered
  4. washwashed with diethyl ether
  5. customdried under vacuum
  6. customsuch without further purification

Sources & evidence

ORD record
ord-99013408221a4cf28fd386bd06d49186
Source dataset
uspto-grants-1998_11
Patent number
US05834493

Reaction notes

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