反应详情

Triethylsilane (22.5 ml; 0.141 mol) was added dropwise to a cold (~0° C.) stirring mixture of 4-chloro-4'-fluoro-butyrophenone (10 ml; 0.0613 mol) in trifluoroacetic acid (47 ml). The reaction mixture was stirred at room temperature under nitrogen for 6 hours. The reaction was quenched with brine and extracted with diethyl ether. The organic extract was dried (MgSO4) and evaporated under vacuum giving the desired compound as an oil.

1. stirringThe reaction mixture was stirred at room temperature under nitrogen for 6 hours
2. customThe reaction was quenched with brine
3. extractionextracted with diethyl ether
4. extractionThe organic extract
5. dry with materialwas dried (MgSO4)
6. customevaporated under vacuum