Iodoethane → HCID 18940931, compound

HRID 356044Notes

Reaction equation

HRID 356044 reaction equation
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([S:14][CH2:15][CH2:16]C)=[C:10]([Br:13])[CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].C([O-])([O-])=O.[K+].[K+].ICC>CS(C)=O>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([S:14][CH2:15][CH3:16])=[C:10]([Br:13])[CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 18940938HCID 18940938, compound

Product 1

HCID 18940931HCID 18940931, compoundYield 100.7%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

The thiol (D79) (0.35 g, 1.29 mmol) was treated with K2CO3 (0.20 g, 1.45 mmol) and iodoethane (0.31 ml, 3.88 mmol) in DMSO (15 ml) at the 50° C. as in the method of Description 80 to afford the title compound (0.39 g, 100%) as a pale yellow solid.

Sources & evidence

ORD record
ord-0a6e6e1d0a4c4736b648b744f81166d5
Source dataset
uspto-grants-1998_11
Patent number
US05834494

Reaction notes

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