Methyl iodide → HCID 10708316, compound

HRID 356045Notes

Reaction equation

HRID 356045 reaction equation
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([S:14][CH2:15]CC)=[C:10]([Br:13])[CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].C([O-])([O-])=O.[K+].[K+].IC>CS(C)=O>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([S:14][CH3:15])=[C:10]([Br:13])[CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 18940938HCID 18940938, compound

Product 1

HCID 10708316HCID 10708316, compoundYield 92.1%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

The thiol (D79) (0.35 g, 1.29 mmol) was treated with K2CO3 (0.20 g, 1.45 mmol) and iodomethane (0.24 ml, 3.85 mmol) in DMSO (15 ml) at 50° C. as in the method of Description 80 to afford the title compound (0.34 g, 92%) as an off-white solid.

Sources & evidence

ORD record
ord-5a13965fc6b64fd0ba70358fb0b19973
Source dataset
uspto-grants-1998_11
Patent number
US05834494

Reaction notes

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