Hydrochloric Acid → HCID 70049849, compound

HRID 356139Notes

Reaction equation

HRID 356139 reaction equation
C(OC([NH:8][C@@H:9]([CH2:28][CH:29]([CH3:31])[CH3:30])[C:10]([NH:12][C@@H:13]([CH2:24][CH2:25][CH2:26][CH3:27])[C:14](=[O:23])[CH2:15][S:16][CH2:17][C:18]1[O:22][CH:21]=[CH:20][CH:19]=1)=[O:11])=O)(C)(C)C.[ClH:32].CCCCCC>C(OCC)(=O)C>[ClH:32].[NH2:8][C@@H:9]([CH2:28][CH:29]([CH3:30])[CH3:31])[C:10]([NH:12][C@@H:13]([CH2:24][CH2:25][CH2:26][CH3:27])[C:14](=[O:23])[CH2:15][S:16][CH2:17][C:18]1[O:22][CH:21]=[CH:20][CH:19]=1)=[O:11]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8058HexaneHCID 54257267HCID 54257267, compound

Product 1

HCID 70049849HCID 70049849, compoundYield 59%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

(s)-3-((s)-2-tert-Butoxycarbonylamino-4-methylvalerylamino)-1-furfurylthio-2-heptanone (8.47 g) obtained in Example 1 was dissolved in ethyl acetate (25 ml), and 4N hydrogen chloride-containing ethyl acetate solution (25 ml) was added to the solution. After the mixture was stirred at room temperature for 50 minutes, hexane (50 ml) was added to the mixture. Then, the resultant crystals were filtered, and washed with hexane to give the titled product (4.31 g).

Workup

  1. additionwas added to the solution
  2. filtrationThen, the resultant crystals were filtered
  3. washwashed with hexane

Sources & evidence

ORD record
ord-f151ed142f3548dd9aef931ae39f981b
Source dataset
uspto-grants-1998_11
Patent number
US05834508

Reaction notes

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