Hydrochloric Acid → HCID 70111966, compound

HRID 356172Notes

Reaction equation

HRID 356172 reaction equation
[C:1]1(=[O:36])[N:5]([CH2:6][C:7]([N:9]2[C@@H:15]3[CH2:16][CH2:17][CH2:18][C@@H:14]3[C:13](=[O:19])[N:12]([CH2:20][C:21]3[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=3)[C:11]3[CH:27]=[CH:28][CH:29]=[CH:30][C:10]2=3)=[O:8])[C:4](=[O:31])[C:3]2=[CH:32][CH:33]=[CH:34][CH:35]=[C:2]12.[ClH:37]>C(O)C.C(OCC)C>[ClH:37].[C:4]1(=[O:31])[N:5]([CH2:6][C:7]([N:9]2[C@@H:15]3[CH2:16][CH2:17][CH2:18][C@@H:14]3[C:13](=[O:19])[N:12]([CH2:20][C:21]3[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=3)[C:11]3[CH:27]=[CH:28][CH:29]=[CH:30][C:10]2=3)=[O:8])[C:1](=[O:36])[C:2]2=[CH:35][CH:34]=[CH:33][CH:32]=[C:3]12

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 70110022(3aR*,10aS*)-4-(phthalimidoacetyl)-9-(3-pyridylmethyl)-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][1,4]diazepin-10(1H)-one

Product 1

HCID 70111966HCID 70111966, compound

Reagents, catalysts & solvents 1

HCID 21585056Diethyl ether ethanolSolvent

Procedure

The (3aR*,10aS*)-4-(phthalimidoacetyl)-9-(3-pyridylmethyl)-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][1,4]diazepin-10(1H)-one, which was obtained in Working Example 116, was made into the corresponding hydrochloride in substantially the same manner as in Working Example 118. m.p. 192°-197° C. (ethanol-diethylether).

Sources & evidence

ORD record
ord-6bc661b405d24d6392ea375d1feaaf55
Source dataset
uspto-grants-1998_11
Patent number
US05834463

Reaction notes

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