Bromoacetyl bromide → HCID 70113834, compound

HRID 356192Notes

Reaction equation

HRID 356192 reaction equation
[CH2:1]([N:8]1[C:14](=[O:15])[C@H:13]2[CH2:16][CH2:17][CH2:18][C@H:12]2[NH:11][C:10]2[CH:19]=[CH:20][C:21]([Cl:23])=[CH:22][C:9]1=2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Br:24][CH2:25][C:26](Br)=[O:27]>C(OCC)(=O)C.CCCCCC>[CH2:1]([N:8]1[C:14](=[O:15])[C@H:13]2[CH2:16][CH2:17][CH2:18][C@H:12]2[N:11]([C:26](=[O:27])[CH2:25][Br:24])[C:10]2[CH:19]=[CH:20][C:21]([Cl:23])=[CH:22][C:9]1=2)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 61147Bromoacetyl bromideHCID 70109608HCID 70109608, compound

Product 1

HCID 70113834HCID 70113834, compoundYield 50%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Using (3aR*,10aS*)-9-benzyl-7-chloro-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][1,4]-diazepin-10(1H)-one and bromoacetyl bromide, the titled compound was synthesized in substantially the same manner as in Working Example 122 in a yield of 50%, m.p. 163°-164° C. (ethyl acetate-hexane).

Sources & evidence

ORD record
ord-013366a5e2ea448a86ddca5508546ba1
Source dataset
uspto-grants-1998_11
Patent number
US05834463

Reaction notes

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