Bromoacetyl bromide → HCID 70113643, compound

HRID 356193Notes

Reaction equation

HRID 356193 reaction equation
[F:1][C:2]1[CH:23]=[CH:22][CH:21]=[CH:20][C:3]=1[CH2:4][N:5]1[C:11](=[O:12])[C@H:10]2[CH2:13][CH2:14][CH2:15][C@H:9]2[NH:8][C:7]2[CH:16]=[CH:17][CH:18]=[CH:19][C:6]1=2.[Br:24][CH2:25][C:26](Br)=[O:27]>C(OCC)(=O)C.CCCCCC>[Br:24][CH2:25][C:26]([N:8]1[C@@H:9]2[CH2:15][CH2:14][CH2:13][C@@H:10]2[C:11](=[O:12])[N:5]([CH2:4][C:3]2[CH:20]=[CH:21][CH:22]=[CH:23][C:2]=2[F:1])[C:6]2[CH:19]=[CH:18][CH:17]=[CH:16][C:7]1=2)=[O:27]

Participants

4

Reactant 2

HCID 61147Bromoacetyl bromideHCID 70112233HCID 70112233, compound

Product 1

HCID 70113643HCID 70113643, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Using (3aR*,10aS*)-9-(2-fluorobenzyl)-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][1,4]-diazepin-10(1H)-one and bromoacetyl bromide, the titled compound was synthesized in substantially the same manner as in Working Example 122 in a yield of 62%, m.p. 198.5°-199.6° C. (ethyl acetate-hexane).

Sources & evidence

ORD record
ord-5a6c62ad6e384b6ca7a944270f238528
Source dataset
uspto-grants-1998_11
Patent number
US05834463

Reaction notes

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