4-Pyridinecarboxaldehyde → HCID 18940621, compound

HRID 356197Notes

Reaction equation

HRID 356197 reaction equation
[CH2:1]([N:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[N:12]=[C:11]([CH3:19])[CH2:10][C:9]1=[O:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:21](=O)[C:22]1[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=1>C(OCC)C>[CH2:1]([N:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[N:12]=[C:11](/[CH:19]=[CH:21]/[C:22]2[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=2)[CH2:10][C:9]1=[O:20])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 133894-PyridinecarboxaldehydeHCID 18940576HCID 18940576, compound

Product 1

HCID 18940621HCID 18940621, compoundYield 36%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Using 1-benzyl-4-methyl-1,3-dihydro-1,5-benzodiazepin-2(2H)-one and isonicotinaldehyde, the titled compound was synthesized in substantially the same manner as in Working Example 144 in a yield of 36%, m.p. 208°-210° C. (diethyl ether).

Sources & evidence

ORD record
ord-0902b722e6874292b5d24d743e86e31c
Source dataset
uspto-grants-1998_11
Patent number
US05834463

Reaction notes

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