反应详情

A mixture of methyl 3-oxo-4-phthalimidobutyrate (15.4 g, 59 mmol), o-phenylenediamine (6.37 g, 59 mmol) and xylene (150 mL) was refluxed for 20 minutes using Dean-Stark apparatus. The reaction mixture was cooled, and resulting crystals were collected by filtration and washed with toluene to give the object compound (15.36 g, 81%), m.p.244°-246° C.

1. temperaturewas refluxed for 20 minutes
2. temperatureThe reaction mixture was cooled
3. customresulting crystals
4. filtrationwere collected by filtration
5. washwashed with toluene