Bromoacetyl bromide → HCID 70111628, compound

HRID 356216Notes

Reaction equation

[C:1]1([CH2:7][CH2:8][N:9]2[C:15](=[O:16])[C@H:14]3[CH2:17][CH2:18][CH2:19][C@H:13]3[NH:12][C:11]3[CH:20]=[CH:21][CH:22]=[CH:23][C:10]2=3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:24][CH2:25][C:26](Br)=[O:27]>>[Br:24][CH2:25][C:26]([N:12]1[C@@H:13]2[CH2:19][CH2:18][CH2:17][C@@H:14]2[C:15](=[O:16])[N:9]([CH2:8][CH2:7][C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:10]2[CH:23]=[CH:22][CH:21]=[CH:20][C:11]1=2)=[O:27]

Participants

Reactant 2

HCID 61147Bromoacetyl bromide

HCID 70112258HCID 70112258, compound

Product 1

HCID 70111628HCID 70111628, compoundYield 72%

Procedure

Employing (3aR*,10aS*)-9-(2-phenylethyl)-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta-[e][1,4]diazepin-10(1H)-one and bromoacetyl bromide, the titled compound was synthesized by substantially the same procedure as in Working Example 185. Yield 72%. Oily product.

Sources & evidence

ORD record: ord-a7b1e858a84a4b44ab593e0f130f3029
Source dataset: uspto-grants-1998_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05834463

Reaction notes

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